Publications

Does obesity affect treatment response to secukinumab and survival in ankylosing spondylitis? Real-life data from the TURKBIO Registry

Modern Rheumatology. 2024;34(3):584–91 doi: 10.1093/mr/road061

Karakaş A,

Gulle S,

Can G,

Dalkılıc E,

Aktar S,

Koca SS,

Pehlivan Y,

Senel S,

Tufan A,

Ozturk MA,

Yilmaz S,

Yazici A,

Cefle A,

Inel TY,

Erez Y,

Sari I,

Merih Birklik,

Direskeneli H,

Akkoc N,

and Onen F.

This study by Karakas, et al. found that obesity did not affect secukinumab treatment response and drug retention in ankylosing spondylitis patients.

Keywords:

• ASAS,
• Efficacy,
• Recommendations,
• Secukinumab

乾癬性関節炎に対するウパダシチニブの有効性と安全性: フェーズ3 SELECT-PsA 1 試験の2年結果

Rheumatol Ther. 2022 Oct 15:1–18 doi: 10.1007/s40744-022-00499-w

McInnes IB,

Kato K,

Magrey M,

Merola JF,

Kishimoto M,

Haaland D,

Chen L,

Duan Y,

Liu J,

Lippe R,

Wung P

Results from the long-term extension of SELECT-PsA 1 show efficacy responses similar or greater with upadacitinib, 15 or 30mg, versus adalimumab through 104 weeks.

Keywords:

• JAK,
• Updacitinib,
• Phase 3,
• LTE

活動性のX線基準を満たさない体軸型脊椎関節炎に対するウパダシチニブ (SELECT-AXIS 2): 無作為化二重盲検プラセボ対照, Phase 3 試験

Lancet 2022 doi: 10.1016/S0140-6736(22)01212-0

Deodhar A,

Van den Bosch F,

Poddubnyy D,

Maksymowych WP,

van der Heijde D,

Kim TH,

Kishimoto M,

Blanco R,

Duan Y,

Li Y,

Pangan AL,

Wung P,

Song IH

Upadacitinib significantly improved the signs and symptoms of nr-axSpA compared with placebo at Week 14 in this investigation. Prior to this, upadacitinib had been shown to be effective in patients with AS. This study aimed to assess the efficacy and safety of upadacitinib in non-radiographic axial spondyloarthritis.

Keywords:

• JAK,
• Updacitinib,
• Phase 3

Upadacitinib in patients with psoriatic arthritis and an inadequate response to non-biological therapy: 56-week data from the phase 3 SELECT-PsA 1 study

RMD Open. 2021;7(3):e001838

McInnes IB,

Kato K,

Magrey M,

Merola JF,

Kishimoto M,

Pacheco-Tena C,

Haaland D,

Chen L,

Duan Y,

Zueger P,

Liu J,

Lippe R,

Pangan AL,

Behrens F

Analysis of data over 56 weeks shows that efficacy responses are maintained with upadacitinib 15 mg and 30 mg.Following the publication of 12-week data from the Phase III, randomised double-blind, SELECT-PsA 1 study, earlier this year, McInnes, et al. now report the 56-week efficacy and safety data of upadacitinib 15 mg and 30 mg in patients with PsA and an inadequate response to non-biological therapyEfficacy responses and inhibition of radiographic progression were maintained with upadacitinib...

Keywords:

• JAK,
• Updacitinib,
• Phase 3

フィルゴチニブの安全性と有効性: 関節リウマチ第二相 試験のオープンラベル長期試験から4年の結果

J Rheumatol. 2021 Feb 1:jrheum.201183. DOI: 10.3899/jrheum.201183.

Kavanaugh A,

Westhovens RR,

Winthrop KL,

Lee SJ,

Tan Y,

An D,

Ye L,

Sundy JS,

Besuyen R,

Meuleners L,

Stanislavchuk M,

Spindler AJ,

Greenwald M,

Alten R,

Genovese MC

A long-term extension study of filgotinib showed consistent safety profile and sustained efficacy with the drug for up to four years. The DARWIN 3 study, for patients who previously completed either the 24-week DARWIN 1 study (filgotinib + MTX) or the DARWIN 2 study (filgotinib monotherapy), enrolled 739 patients with RA. At the time of analysis, 440 patients had received four years or more of filgotinib. Exposure-adjusted incidence rate per 100 patient-years-of-exposure for TEAEs was 24.6 in th...

Keywords:

• JAK,
• Fenebrutinib,
• Phase 2,
• LTE

JAK1 阻害薬であるフィルゴチニブは, 関節リウマチに関連するバイオマーカーを調節する: 2つのランダム化対照フェーズ2b試験結果

Rheumatol Ther. 2020 DOI: 10.1007/s40744-019-00192-5

Tarrant JM,

Galien R,

Wanying L,

Goyal L,

Pan Y,

Hawtin R,

Zhang W,

Van der Aa A and Taylor PC

In this study examining the effect of FIL on a panel of biomarkers, FIL down-modulated several key inflammatory mediators of signalling pathways in RA - independent of MTX background therapy. This confirmed the strong network effects of the JAK1 node in autoimmunity, matrix and cartilage degradation, angiogenesis, and leukocyte adhesion and recruitment. Biomarkers key to RA pathophysiology were measured at baseline, Wk4 and Wk12 in FIL 100 mg, FIL 200 mg or PBO treatment groups from two phase 2b...

Keywords:

• JAK,
• Filgotinib,
• Phase 2,
• MOA,
• Biomarkers

ヤヌスキナーゼ阻害薬が関節リウマチ患者の心血管イベントに及ぼすリスク: 無作為化試験のシステマティックレビューとメタ解析

Ann Rheum Dis. 2019 Aug;78(8):1048-1054.

Xie W,

Huang Y,

Xiao S,

Sun X,

Fan Y,

Zhang Z

Existing evidence from RCTs indicated no significant change in CV risk for JAK inhibitor (JAKinib) treated RA patients in a short-term perspective compared to placebo.Patients with RA have an elevated risk of CV morbidity and mortality, which cannot be fully explained by traditional CV risk factors. Reaching remission or LDA in order to reduce CV events (CVE) is encouraged in the current EULAR recommendations. JAKinibs and their roles in the modulation of CV risk remain undetermined. This study ...

Keywords:

• JAK,
• Safety,
• Meta analysis,
• Cardiovascular

中国人関節リウマチ患者における従来型合成抗リウマチ薬併用トファシチニブ: 無作為化対照フェーズ3試験からの患者立脚型評価

Int J Rheum Dis 2018; 21(2):402–14

Li Z,

An Y,

Su H,

Li H,

Xu J,

Zheng Y,

Li G,

Kwok K,

Wang L,

Wu Q

This Chinese sub-population of patients with RA from ORAL Sync reported significant improvements in patient-reported outcomes (PROs), which were maintained up to 12 months from tofacitinib (TOF) treatment initiation. ORAL Sync was a randomised, Phase 3 study investigating TOF therapy in combination with csDMARDs in patients with active RA who had previously had an inadequate response to csDMARDs. To date, this is the only Phase 3 study of TOF in patients from China with RA. This analysis include...

Keywords:

• JAK,
• Phase 3

Super-enhancers delineate disease-associated regulatory nodes in T cells

Nature. 2015 Feb 16. doi: 10.1038/nature14154. [Epub ahead of print]

Vahedi G,

Kanno Y,

Furumoto Y,

Jiang K,

Parker SC,

Erdos MR,

Davis SR,

Roychoudhuri R,

Restifo NP,

Gadina M,

Tang Z,

Ruan Y,

Collins FS,

Sartorelli V,

O'Shea JJ.

Transcription machinery (proteins responsible for activating or ‘switching off’ genes) is not distributed in the genome in a symmetrical (or even) manner. Some parts of the genome, so called super-enhancers (SEs), accumulate an exceptionally high level of proteins relevant to the regulation of transcription (i.e. the machinery is concentrated in particular parts of the genome). In this paper, the investigators asked about the locale of these regions in the genome of T cells. Then they addressed...

Keywords:

• Preclinical,
• MOA

Ibrutinib and novel BTK inhibitors in clinical development

Journal of Hematology & Oncology 2013;6:59

Akinleye A,

Chan Y,

Mukhi N et al.

Bruton’s tyrosine kinase (BTK) is a part of the cytokine signalling pathways involved in malignancies and autoimmune disorders.. Akinleye et al. provide a review of all the current BTK inhibitors in preclinical and clinical trials for B-cell malignancies and autoimmune disorders, including rheumatoid arthritis. Particular focus is placed on ibrutinib, a novel human BTK-inhibitor, currently in phase III clinical trials. The authors also discuss four new compounds with potential indications in rh...

Keywords:

• BTK,
• Ibrutinib