Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Modeling of Filgotinib (GLPG0634), a Selective JAK1 Inhibitor, in Support of Phase IIB Dose Selection
Clin Pharmacokinet. 2015 Feb 14. [Epub ahead of print]
Two phase I, randomised, double-blind, placebo-controlled trials in healthy volunteers and one phase IIa proof-of-concept study in RA patients were used to evaluate single and multiple doses of filgotinib.
Keywords:
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Nat Med. 2015 Feb 16. doi: 10.1038/nm.3806. [Epub ahead of print]
Professor O'Neill and his team have identified MCC950 as a potent, selective, small-molecule inhibitor of the NLRP3 infla...
Keywords:
January 2015
Potential Mechanisms Leading to the Abnormal Lipid Profile in Patients With Rheumatoid Arthritis Versus Healthy Volunteers and Reversal by Tofacitinib
Arthritis Rheumatol. 2015;67(3):616-25.
Keywords:
Efficacy and Safety of Tofacitinib as Monotherapy in Japanese Patients With Active Rheumatoid Arthritis: A 12-Week, Randomized, Phase 2 Study
Mod Rheumatol. 2014 Dec 11:1–25. [Epub ahead of print]
The oral JAK inhibitor tofacitinib has demonstrated efficacy as monotherapy or in combination with DMARDs ...
Keywords:
The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers
Mod J Clin Pharmacol. 2014 Dec;54(12):1354-61. doi: 10.1002/jcph.354.
Keywords:
IL-6 stimulates intestinal epithelial proliferation and repair after injury
PLoS One. 2014 Dec 5;9(12):e114195. doi: 10.1371/journal.pone.0114195. eCollection 2014.
The authors hypothesized that IL-6 may have beneficial properties in wound response/rep...
Keywords:
December 2014
Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate
Ann Rheum Dis. 2015;74(2):333–340
This phase IIb study was designed to investigate multiple doses and dosing regimens of baricitin...
Keywords:
The activity of JAK-STAT pathways in rheumatoid arthritis: constitutive activation of STAT3 correlates with interleukin 6 levels
Rheumatology (Oxford). 2014 Nov 17. pii: keu430. [Epub ahead of print]
Keywords:
The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
Ann Rheum Dis. 2014 Nov 14. pii: annrheumdis-2014-206028. doi: 10.1136/annrheumdis-2014-206028. [Epub ahead of print]
Keywords:
Lipid profile changes in patients with chronic inflammatory arthritis treated with biologics and tofacitinib in randomized clinical trials: A systematic review and meta-analysis
Arthritis Rheumatol. 2015;67(1):117–127
The s...