Publications

View and download slide summaries of the latest original articles focusing on therapies in immune-mediated inflammatory diseases including rheumatology, dermatology, and gastroenterology. All materials produced by the team are subsequently reviewed and approved by individual Steering Committee members.

April 2024

EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2023 update

Ann Rheum Dis 2024 doi: 10.1136/ard-2024-225531 Epub ahead of print

Eder L,

Mauro D,

Nash P,

van der Helm-van Mil A,

Zabotti A,

van der Heijde D,

Smolen JS

The 2023 EULAR recommendations provided an updated consensus on the pharmacological management of PsA with a new overarching principle and recommendation for 2023. Recent MOA safety data emphasised the importance of patient-specific benefit-risk profiling in JAKi therapy, and extra-musculoskeletal (MSK) manifestations related to PsA should be considered during drug selection.

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November 2022

Recommandations ASAS-EULAR pour la prise en charge de la spondylarthrite axiale : mise à jour 2022

Ann Rheum Dis 2022; online ahead of print doi:10.1136/ard-2022-223296

Kiltz U,

Molto A,

Proft F,

Zhao SS,

Ziade N,

van der Heijde D

Since the last update in 2016, more data have become available on existing treatment options for axSpA, and particularly on IL-17i. The increasing availability of more drugs and with different modes of action raises questions around their positioning in the treatment pathway. This review sought to update the 2016 recommendations with newly available evidence.

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ASAS-EULAR

October 2022

Taux de reprise et de retraitement avec l'Ixekizumab après l'arrêt du traitement chez les patients atteints de spondylarthrite axiale : Résultats à la semaine 104 d'une étude de retrait randomisée contrôlée par placebo

Ann Rheum Dis. 2022 doi: 10.1136/ard-2022-222731

Bolce R,

Park SY,

The present analysis demonstrated that patients continuously treated with IXE were less likely to experience flare compared with patients receiving placebo. The aim of this study was to evaluate the recapture of response with open-label IXE retreatment at week 104 in patients with axSpA who flared after withdrawal of IXE therapy.

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July 2021

Upadacitinib chez les patients atteints de rhumatisme psoriasique et ayant une réponse inadéquate aux médicaments biologiques : données de 56 semaines de l'étude randomisée et contrôlée de phase 3 SELECT-PsA 2

Rheumatol Ther. 2021;8(2):903–919

Papp KA,

Tsuji S,

Bu X,

Chen L,

McCaskill RM,

Zueger P,

McDearmon-Blondell EL,

Pangan AL,

Tillett W.

Fifty-six-week data suggest that upadacitinib could be a favourable long-term treatment option in patients with PsA who are refractory to biologic therapy.As the need for additional therapeutic agents that can effectively control disease activity continues, new data from a 56-week analysis of the oral reversible JAK1 inhibitor, upadacitinib, currently under investigation for the treatment of PsA, shows that efficacy of the drug is maintained over the duration of this study.Mease, et al. explored...

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December 2020

Passage de l'Upadacitinib, un Inhibiteur de Janus Kinase, à l'Adalimumab Suite à une Réponse Insuffisante : Efficacité et Innocuité Chez les Patients Atteints de Polyarthrite Rhumatoïde

Ann Rheum Dis 2020; doi:10.1136/annrheumdis-2020-21841220

Hall S,

Li Y,

Song Y,

DeMasi R,

Song I-H

Both ACR and EULAR recommend adding a biologic or targeted synthetic DMARD in patients who do not achieve treatment goals at follow-up. Findings indicated that an immediate switch in mechanism of action (from JAKi to TNFi and vice versa) following treat-to-target principles is feasible with minimal risk of flare regardless of whether patients are switched due to non-response or incomplete-response.SELECT-COMPARE followed treat-to-target principles to examine the efficacy of switching in two pati...