Guselkumab, un inhibidor selectivo de la subunidad p19 de la Interleukina-23, resuelve la dactilitis en pacientes con artritis psoriásica activa: resultados agrupados a lo largo de 52 semanas desde dos estudios de fase 3
ACR Open Rheumatol. 2023;5(4):227–240 doi 10.1002/acr2.11537
Post hoc analysis of guselkumab, Phase 3 DISCOVER-1 and -2 studies finds that 75% of guselkumab-randomised patients have complete resolution of dactylitis through one year.
Dactylitis is a high burden, hallmark symptom within PsA, the resolution of which may be associated with better long-term patient outcomes. To help assess this, McGonagle, et al. sought to examine specific treatment effects of guselkumab across one year, in patients with PsA with and without dactylitis.
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