Le Tofacitinib et le Baricitinib Sont Absorbés Par des Mécanismes Différents Déterminant Leur Efficacité Dans la PR
Int. J. Mol. Sci. 2020; 21:6632 DOI: 10.3390/ijms21186632
Amrhein et al examined the different uptake and expulsion mechanisms of BARI and TOF in cellular assays. Different cellular uptake mechanism for BARI and TOF was observed and showed that BARI’s transport was not dependent on organic cation transporters. Results indicated TOF was exported from RASF in a MATE-1 dependent way. TOF might be exported from healthy cells, thereby not inhibiting JAK pathway in these cellsThe interaction of BARI and TOF with OCTs was investigated using quenching experime...