JAK/STAT pathway and nociceptive cytokine signalling in rheumatoid arthritis and psoriatic arthritis
Clin Exp Rheumatol. 2021;39(3):668-675.
The JAK/STAT pathway is receiving increasing attention in modulation of nociceptive responses, given its clear role in cytokine signalling. The authors of this review speculate that JAKinibs may have an effect on the modulation of nociception and reduction of pain.Crispino N, et al. review the impact of pain in patients with rheumatic disease and the physiological basis of modulating nociceptive pain. They examine the role of cytokines in the modulation of pain and analyse current clinical JAKin...