Publications

View and download slide summaries of the latest original articles focusing on therapies in immune-mediated inflammatory diseases including rheumatology, dermatology, and gastroenterology. All materials produced by the team are subsequently reviewed and approved by individual Steering Committee members.

August 2022

Risankizumab は乾癬性関節炎の健康関連の生活の質, 疼痛, 労働生産性を改善: KEEPsAKE 1

Rheumatology (Oxford) 2022 doi: 10.1093/rheumatology/keac342

Kristensen LE,

Soliman AM,

Papp K,

White D,

Barcomb L,

Lu W,

Eldred A,

Behrens F.

In this study risankizumab treatment resulted in greater improvements in fatigue and pain than placebo. Prior to this finding the study aimed to evaluate the impact of risankizumab on HRQoL and other PROs among patients with active PsA and inadequate response or intolerance to csDMARD-IR in the KEEPsAKE 1 trial.

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May 2021

乾癬性関節炎に対するUpadacitinibとAdalimumabの臨床試験

N Engl J Med. 2021;384(13):1227-1239.

Liu Y,

Jeka S,

Wang X,

Chen L,

Zueger P,

Liu J,

Pangan AL,

Behrens F.

Upadacitinib efficacy proves to be greater than placebo, and non-inferior to adalimumab, in treating patients with psoriatic arthritis (PsA). Already approved for the treatment of rheumatoid arthritis, McInnes, et al. studied oral upadacitinib at a dose of 15 mg or 30 mg, alongside placebo or adalimumab, in this 24-week, Phase III trial, in over 1700 patients with PsA. At the primary endpoint (Week 12), ACR20 response was greater with upadacitinib than placebo, and non-inferior to adalimumab; wi...