September 2023

Traitement par le bimekizumab chez des patients naïfs de DMARD biologiques atteints de rhumatisme psoriasique actif : résultats d'efficacité et de sécurité à 52 semaines de l'étude BE OPTIMAL de phase III, randomisée, contrôlée par placebo et à référence active

Ann Rheum Dis. 2023;82(11):1404–1414 doi: 10.1136/ard-2023-224431

Data from this phase 3 RCT demonstrated that the efficacy of bimekizumab observed at 16 weeks remained consistent through to 52 weeks in the treatment of bDMARD-naïve patients with PsA. Patients who started the trial on placebo and switched to bimekizumab at week 16 showed similar improvements to those patients who were randomised to receive bimekizumab at the start of the trail. No new safety signals were identified.

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Traitement par Upadacitinib dans le rhumatisme psoriasique actif : Données d'efficacité et de sécurité des 192 premiers patients de l'étude UPJOINT, une étude observationnelle multicentrique en pratique clinique

Rheumatol Ther. 2023;10(6):1503–1508 doi: 10.1007/s40744-023-00589-3

In the UPJOINT open label study, the proportion of patients with PsA, and an inadequate response to csDMARDs or bDMARDs, who achieved minimal disease activity with upadacitinib was in line with the results of previous studies at 24 weeks. No new safety signals were identified.

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Le guselkumab modifie les gènes différentiellement exprimés dans le sang des patients atteints de rhumatisme psoriasique : Résultats de deux essais de phase 3, randomisés et contrôlés par placebo

ACR Open Rheumatol. 2023 doi: 10.1002/acr2.11589

Whole blood transcriptome profiling reveals differential gene expression in patients with active PsA from the DISCOVER-1 and DISCOVER-2 clinical studies in comparison with healthy controls.

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Bimekizumab efficacy and safety in patients with moderate to severe plaque psoriasis: Two-year interim results from the open-label extension of the randomized BE RADIANT Phase 3b trial

J Am Acad Dermatol 2023;89:486–95. doi: 10.1016/j.jaad.2023.04.063

High levels of clinical responses were seen throughout the first 48 weeks with bimekizumab treatment. These were maintained to Week 96 in patients with moderate-to-severe plaque PsO.

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Étude de phase 2a randomisée, en double aveugle, contrôlée par placebo, portant sur l'efficacité et l'innocuité du tildrakizumab chez des patients atteints de spondylarthrite ankylosante active

J Clin Rheumatol. 2023;29(5):223–229 doi: 10.1097/RHU.0000000000001973

Phase 2a study assessing the efficacy and safety of tildrakizumab in patients with active AS fails to meet the primary endpoint.

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Safety and efficacy of mirikizumab versus secukinumab and placebo in the treatment of moderate-to-severe plaque psoriasis (OASIS-2): a phase 3, multicentre, randomised, double-blind study

Lancet Rheumatol 2023;5:e542–52. doi: 10.1016/S2665-9913(23)00120-0

Week 16 primary outcomes of improved PASI 90 response and sPGA score demonstrated Mirikizumab superiority to placebo and non-inferiority to secukinumab. This study presented results from the OASIS-2 trial on the safety and efficacy of mirikizumab compared with secukinumab and placebo in patients with moderate-to-severe plaque psoriasis.

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August 2023

Effet de l'Ixekizumab sur les manifestations axiales chez les patients atteints de rhumatisme psoriasique, d'après deux essais cliniques de phase III : SPIRIT-P1 et SPIRIT-P2

Ther Adv Musculoskelet Dis. 2023;15:1759720X231189005 doi: 10.1177/1759720X231189005

Post-hoc analysis of SPIRIT-P1 and SPIRIT-P2 concludes that ixekizumab (IXE) is effective in improving axial symptoms in patients with active PsA presenting with axial manifestations.

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Efficacité du tofacitinib sur l'enthésite chez les patients atteints de rhumatisme psoriasique actif : Analyse des données regroupées de deux études de phase 3

Arthritis Res Ther. 2023 22;25(1):153 doi: 10.1186/s13075-023-03108-5

Post-hoc analysis of two tofacitinib phase three studies concludes that tofacitinib treatment resulted in improvements in enthesitis in patients with PsA, regardless of baseline location or severity.

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Différences et similitudes entre les recommandations EULAR/ASAS-EULAR et les recommandations nationales pour le traitement des patients atteints de rhumatisme psoriasique et de spondylarthrite axiale en Europe

Lancet Reg Health Eur. 2023;33:100706 doi: 10.1016/j.lanepe.2023.100706

Comparing the alignment of European national recommendations for patients with PsA and axSpA with EULAR and ASAS-EULAR treatment recommendations found that only a minority of national treatment recommendations were completely aligned.

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Efficacité et innocuité du brepocitinib, inhibiteur de TYK2/JAK1, dans le traitement du rhumatisme psoriasique actif : Essai contrôlé randomisé de phase IIb

Arthritis Rheumatol. 2023;75(8):1370–1380 doi: 10.1002/art.42519

Phase IIb study of brepocitinib in patients with PsA concludes that treatment with brepocitinib 30 mg and 60 mg QD, was superior to placebo at reducing signs and symptoms of PsA and was well-tolerated over 52 weeks.

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