Publications

The authors found that there is a reduction in effectiveness of lines of bDMARDs after first-line in PsA, with inadequate data to determine response to tsDMARDs.

This investigation aimed to assess current evidence for effectiveness of sequential lines of b/tsDMARDs when used beyond first line for PsA. There is some observational data indicating that advanced lines of b/tsDMARDs can be effective for patients with PsA. This suggests that benefits can be obtained by appropriate b/tsDMARD switching. The current evidence available however indicates that the effectiveness of advanced lines of b/tsDMARD therapy in the treatment of PsA is primarily observational and at a high risk of bias.