Modulation of IL-23 Signalling with Guselkumab in Biologic-Naïve Patients Versus TNF Inhibitor-Inadequate Responders with Active Psoriatic Arthritis

Arthritis Rheumatol 2024 doi 10.1002/art.42803 Epub ahead of print

Guselkumab treatment exhibited generally comparable and significant pharmacodynamic effects on IL-23/Th17–associated cytokines across participants with PsA who are biologic-naïve or have TNFi-IR. In coming to this conclusion, investigators assessed and compared immunologic differences and associations with clinical response to guselkumab in participants with active PsA who were biologic-naïve or TNFi-IR.

In addition, associations were observed between elevated baseline levels of IL-22, IL-17A, and BD-2 with the achievement of robust skin responses at Week 24 in TNFi-IR participants. This suggest guselkumab may play an important role in modulating aberrant IL-23/Th17 cell–mediated signalling in this difficult-to-treat population.

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