Publications

View and download slide summaries of the latest original articles focusing on therapies in immune-mediated inflammatory diseases including rheumatology, dermatology, and gastroenterology. All materials produced by the team are subsequently reviewed and approved by individual Steering Committee members.

October 2020

Baricitinib, Médicament Ayant un Effet Potentiel Pour Empêcher le SARS-COV-2 de Pénétrer dans les Cellules Cibles et Contrôler la Tempête Cytokinique Induite par COVID-19

Journal of International Immunopharmacology. 2020 Sep;86:106749. doi: 10.1016/j.intimp.2020.106749.

Zhang X,

Zhang Y,

Qiao W,

Zhang J,

Qi Z

BARI may potentially interrupt the passage of SARS-CoV-2 into the target cells by binding to AAK1 and GAK, which are regulators of the ACE2 receptor regulator identified for its uptake, and could also treat cytokine storm through suppression JAK1/JAK2. Professor Zhang and et al reviewed BARI, as a potential drug to prevent SARS-COV-2 from entering target cells. They also evaluated BARI’s ability to control COVID-19 induced cytokine storm. As a cell surface protein, ACE2 is involved in receptor-m...

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June 2020

Baricitinib Chez les Patients Atteints de Polyarthrite Rhumatoïde Ayant une Réponse Inadéquate au Méthotrexate : Résultats d'une Étude de Phase 3

Clin Exp Rheumatol . Jul-Aug 2020;38(4):732-741. Epub 2020 May 20.

Li Z,

Hu J,

Bao C,

Li X,

Xu J,

Spindler AJ,

Zhang X,

Xu J,

He D,

Li Z,

Wang G,

Yang Y,

Wu H,

Ji F,

Tao H,

Zhan L,

Bai F,

Rooney TP,

Zerbini CAF

This study conducted mainly in Chinese patients with RA, and an inadequate response to MTX, showed that baricitinib 4mg was associated with significant improvements and consistent with the findings from previous clinical trials.The efficacy and safety of baricitinib have been assessed in several clinical trials, predominantly in Caucasian populations. However, evidence on the efficacy and safety of baricitinib in Chinese patients is limited, with only one of the main clinical trial program studi...

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September 2019

Comparaison du Baricitinib, Upadacitinib et Tofacitinib médié par la régulation de la signalisation des cytokines dans les sous-populations de leucocytes humains

Arthritis Res Ther. 2019 Aug 2;21(1):183

Lee J,

Na S,

Rocha G,

Zhang X,

Different JAKinibs modulated distinct cytokine pathways to varying degrees, and no agent potently or continuously inhibited an individual cytokine signalling pathway throughout the dosing interval. This study aimed to compare the in vitro cellular pharmacology of BARI, TOF and UPA across relevant leukocyte subpopulations, coupled with their in vivo PK, to determine their effects on distinct cytokine pathways. Peripheral blood mononuclear cells from healthy donors were incubated with different JA...

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February 2019

Innocuité Cardiovasculaire Pendant le Traitement par Baricitinib dans la Polyarthrite Rhumatoïde

Arthritis Rheumatol. 2019 Jul;71(7):1042-1055.

Witt S,

Issa M,

Zhang X,

This study indicates no association between exposure to BARI and MACE, arterial thrombotic events (ATE), or congestive heart failure (CHF). Overall IRs for venous thromboembolic event (VTE) in BARI-treated patients falls within the reported range for patients with RA.RA patients have a greater risk of cardiovascular (CV) diseases of arterial ischemic origin, and an increased risk of VTE. Studied frequencies of thromboembolic events in RA populations in the last decade has been reported as 2–3x h...