A disease-associated gene desert directs macrophage inflammation through ETS2
Nature 2024 doi: 10.1038/s41586-024-07501-1 Epub ahead of print
Stankey, et al. used functional genomics to show that the ETS2 gene is a central regulator of human inflammatory macrophages. They also found that ETS2 was disrupted by JAK inhibitors and MEK inhibitors, with multiple MEK inhibitors being shown to downregulate ETS2-target genes.
Functional genomics, including CRISPR–Cas9, were used to determine the effect of ETS2 on macrophage inflammation. The authors also used a database of cellular signatures to identify drugs that may modulate the ETS2 pathway.
