Upadacitinib Induction and Maintenance Therapy for Crohn’s Disease
N Engl J Med 2023; 388:1966–1980 doi: 10.1056/NEJMoa2212728
Upadacitinib was associated with higher percentages of remission and endoscopic response regardless of previous failure of biologic therapy. This paper reports the Phase 3 efficacy and safety results of upadacitinib in patients with moderate-to-severe Crohn’s disease.
Significantly more patients receiving upadacitinib 45mg versus placebo achieved the co-primary endpoints at Week 12, including clinical remission and endoscopic response.
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