Risque d'événements cardiovasculaires majeurs dans les troubles inflammatoires à médiation immunitaire sous l'effet de produits biologiques et de petites molécules : Méta-analyse en réseau
CClin Gastroenterol Hepatol 2023;22:961-970.e12
The results of this study show that anti-IL-12/23, JAK inhibitors, and anti-TNF-α were associated with slightly higher risk of MACE compared with placebo. The risk was no different between biologic treatments, and the magnitude of risk did not differ between IMID type.
This meta-analysis by Mattay, et al. included 40 studies and compared MACE incidence between IMID patients treated with JAKi, anti-TNFs, anti-IL-23, anti-IL-12/23, and placebo.
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