Risco de Eventos Cardiovasculares Adversos Maiores em Distúrbios Inflamatórios Imunomediados com Biológicos e Moléculas Pequenas: Meta-análise em rede
Clin Gastroenterol Hepatol. 2023 Oct 9:S1542-3565(23)00767-X doi 10.1016/j.cgh.2023.09.033 Epub ahead of print
The results of this study show that anti-IL-12/23, JAK inhibitors, and anti-TNF-α were associated with slightly higher risk of MACE compared with placebo. The risk was no different between biologic treatments, and the magnitude of risk did not differ between IMID type.
This meta-analysis by Mattay, et al. included 40 studies and compared MACE incidence between IMID patients treated with JAKi, anti-TNFs, anti-IL-23, anti-IL-12/23, and placebo.
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