Data from an international collaboration of registries show no evidence of an increase in CV events during the first 2 years of use with JAKi, compared to TNFi, in the general RA population.

Strand et al. showed that TOF was efficacious across both sexes, with higher responses in males observed particularly for more stringent composite endpoints and PROs. Authors conducted a post hoc analysis of placebo-controlled RCTs to evaluate TOF efficacy, safety, and persistence by sex, and explored whether age-related factors contribute to differences in treatment response between males and females.

This real-world analysis from the RA-BE-REAL study evaluated early achievement of remission or LDA at 3 months and long-term outcomes at 24 months in adults with RA starting baricitinib or other b/tsDMARDs. Patients who achieved remission/LDA at 3 months experienced greater improvements in pain, physical function, and quality of life compared with patients who did not.

Temiz et al. showed that this long-term data provides strong evidence that BARI maintains its clinical efficacy, drug survival and acceptable safety profile as monotherapy over several years in a real-world setting. Authors evaluated the long-term efficacy, drug survival and safety of BARI monotherapy versus combination therapy in a prospective cohort of patients with RA.

In this real-world study, Baraliakos, et al. SC IFX demonstrated clinical effectiveness in both
r- and nr-axSpA, with consistent results across diverse patient characteristics. Both physicians and patients reported high satisfaction with no new safety concerns. Authors assessed the real-world outcomes of CT-P13 SC (SC IFX) as treatment for both r- and
nr-axSpA.

Bakay et al. report  that upadacitinib (UPA) demonstrated sustained efficacy across musculoskeletal and skin domains in PsA patients with prior inadequate response to TNF inhibitors, with a safety profile consistent with previous reports.  Authors conducted a retrospective, single-centre observational study evaluating musculoskeletal disease activity, psoriasis, and patient-reported outcomes following initiation of UPA.

Gollins et al. reported that within this cohort, the Psoriatic arthritis response criteria (PsARC) response to 4^th+ lines of b/tsDMARD was not significantly reduced compared with 2^nd/3^rd line in participants who had failed at least 3 b/tsDMARDs. Authors evaluated the primary clinical response to sequential lines of b/tsDMARD therapy in PsA, focusing on the effectiveness of later line treatments.

Diamanti et al. showed that after 12 months of UPA treatment, a substantial proportion of RA patients achieved combined clinical and US remission, independent of prior bDMARD use or monotherapy. In the preliminary data from the UPARAREMUS study, authors reported efficacy of UPA in achieving both clinical and US remission up to 24 weeks in 60 RA patients.

This large French nationwide study by Fautrel et al. provided reassuring results for patients, who initiated tocilizumab (TCZ), aged at least 75 years compared to younger patients. Authors compared patient characteristics, tolerance of RA treatments, and long-term management with TCZ in patients with RA over and under 75 years of age.

Bai et al. reported that JAKi therapy was associated with a reduced risk of incident uveitis compared with TNF inhibitors among patients with AS, PsO, or PsA. Authors conducted a large-scale, real world comparative study which evaluated the risk of incident uveitis among patients with psoriatic disease and AS treated with either TNFi or JAKi.