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Showing 2 results for “Ortmann RA”.

September 2019

Comparação da Regulação da Sinalização de Citoquinas Mediada por Baricitinib, Upadacitinib e Tofacitinib em Subpopulações de Leucócitos Humanos

Arthritis Res Ther. 2019 Aug 2;21(1):183

Different JAKinibs modulated distinct cytokine pathways to varying degrees, and no agent potently or continuously inhibited an individual cytokine signalling pathway throughout the dosing interval. This study aimed to compare the in vitro cellular pharmacology of BARI, TOF and UPA across relevant leukocyte subpopulations, coupled with their in vivo PK, to determine their effects on distinct cytokine pathways. Peripheral blood mononuclear cells from healthy donors were incubated with different JA...

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July 2019

Desfechos Clínicos em Pacientes que Trocaram de Adalimumab para Baricitinib devido a Falta de Resposta e/ou Desenho do Estudo: Fase 3 em Pacientes com Artrite Reumatoide

Ann Rheum Dis. 2019 Jul;78(7):890-898.

Switching from ADA to BARI without a lengthy washout period can be executed with acceptable safety and tolerability and was associated with maintained disease control. Switching therapies in RA is commonplace in myriad scenarios including inadequate responses, intolerances and patient preference. Assessing the safety and efficacy of new treatments such as BARI, in the context of use as a replacement therapy, is beneficial. A previous study (RA-BEACON) has demonstrated that safely switching from ...

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