Graduale Riduzione versus Regime Stazionario del Methotrexate in combinazione con Tocilizumab per l’Artrite Reumatoide: un Trial Randomizzato in Doppio Cieco
Rheumatology (Oxford) 2018;57(1):84–91
Methotrexate (MTX) tapering in patients with active, severe RA receiving intravenous tocilizumab (TCZ) was non-inferior to continuing stable MTX doses in maintaining a good/moderate EULAR response. Although MTX and bDMARD combination therapy may produce better response rates than bDMARD monotherapy, one third of patients discontinue or are non-compliant with MTX due to preference or toxicity. This randomised, non-inferiority study investigated the efficacy and tolerability of MTX tapering and ma...