Upadacitinib en Artritis Reumatoide: Una Evaluación de Riesgo-Beneficio en el Programa de Fase III
Drug Saf. 2021 Feb 2. DOI: 10.1007/s40264-020-01036-w
Upadacitinib 15 mg has a favourable benefit–risk profile according to an assessment of data from the phase III SELECT clinical trial programme.In this review of data for the once-daily, oral JAK inhibitor, Conaghan PG, et al. provided insights into the benefit–risk profile of upadacitinib in approximately 4400 patients with RA. Based on pooled data from five pivotal studies, benefits and risks were assessed up to the time of regulatory submission, and additional long-term integrated safety revie...