September 2022

Impact du traitement initial par upadacitinib ou adalimumab sur l'atteinte des objectifs thérapeutiques à 48 semaines chez les patients atteints de polyarthrite rhumatoïde : analyse post hoc de SELECT-COMPARE

Rheumatology (Oxford). 2022. Epub ahead of print doi: 10.1093/rheumatology/keac477

Post hoc analysis findings provide the first data evaluating the importance of treatment order with JAKinib vs TNFi as initial therapy, suggesting that a JAKinib first strategy leads to more rapid improvements in treatment outcomes following csDMARD failure.

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Infections chez les patients atteints de polyarthrite rhumatoïde recevant du tofacitinib versus des inhibiteurs du facteur de nécrose tumorale : résultats de l'essai de Surveillance ORAL ouvert, randomisé et contrôlé

doi: 10.1136/ard-2022-222405

Post hoc analysis, using the final dataset from ORAL Surveillance, reveals a higher risk of non-serious infections and herpes zoster with tofacitinib vs TNFi, and higher risk of serious infection events with tofacitinib 10 mg BID versus TNFi, particularly in patients aged ≥65 years.

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Consensus statement on blocking interleukin-6 receptor and interleukin-6 in inflammatory conditions: an update

doi: 10.1136/ard-2022-222784.

Blocking the IL-6R is a major therapeutic advance for many diseases in adults and children. Updated consensus statement provides guidance to rheumatologists and other experts, as well as patients and administrators, on managing patients with the use of drugs blocking the IL-6 pathway.

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August 2022

Zona incident et récurrent chez les patients séropositifs atteints de polyarthrite rhumatoïde et traités par bDMARD ou tsDMARD en première intention : une étude de cohorte à l'échelle nationale

Arthritis Res Ther. 2022;24(1):180

Herpes zoster (HZ) risk is significantly increased in seropositive RA patients with a history of HZ after the initiation of bDMARDs or tsDMARD. It is now well known that the incidence and recurrence of HZ are quite common in patients with RA in real-world clinical settings, yet there is limited evidence regarding bDMARD-dependent HZ risk among patients with a history of HZ prior to bDMARD use.

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July 2022

Efficacité et innocuité de l'upadacitinib dans la spondylarthrite ankylosante active réfractaire au traitement biologique : Un essai de phase 3 en double aveugle, randomisé et contrôlé par placebo

Ann Rheum Dis 2022 doi:10.1136/annrheumdis-2022-222608

Van der Heijde et al., carried out a study to show whether upadacitinib offers an effective treatment option for bDMARD-naïve and bDMARD-IR patients with active AS. Their results indicated that upadacitinib 15 mg significantly improved the signs and symptoms of active AS. The treatment was well tolerated for 14 weeks in bDMARD-IR patients, consistent with results observed in the upadacitinib AS bDMARD-naïve study.

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Facteurs associés à la rémission sans médicament à 5 ans chez les patients atteints de spondylarthrite axiale récente : Données de la cohorte DESIR

Joint Bone Spine. 2022 doi.org/10.1016/j.jbspin.2022.105358

This study from Ruyssen-Witrand et al, highlights that the probability of being in drug free remission at 5-year in patients with recent onset of axSpA is low. The study was performed to investigate the possible association between demographic, clinical, biological and imaging characteristics and drug-free remission at 5 years.

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Le risque d'infection est-il plus élevé pendant le traitement par sécukinumab que par inhibiteurs du TNF ? Une étude observationnelle dans les pays nordiques

Rheumatology (Oxford). 2022 doi: 10.1093/rheumatology/keac358

Glintborg B et al, highlight in their recent research from the Nordic countries, that there is a low frequency of hospitalised infections during treatment with secukinumab or TNFi in patients with SpA and PsA. In clinical practice, secukinumab was found to double absolute risk of 1st year hospitalised infection compared with adalimumab, with the other TNFi treatments falling in between.

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L'activité initiale de la maladie permet de prédire l'atteinte des objectifs thérapeutiques cDAPSA avec Apremilast : Résultats de phase III chez des patients atteints de rhumatisme psoriasique et DMARD-naïfs

J Rheumatol. 2022 doi: 10.3899/jrheum.210906

Baseline disease activity, as measured by cDAPSA, predicts the achievement of treatment targets in DMARD-naïve patients post- apremilast treatment. To come to this conclusion Mease, et al.  analysed data from the PALACE 4 clinical trial which investigated apremilast in DMARD-naïve patients. 175 patients receiving 30mg apremilast from baseline with cDAPSA data available, were analysed.

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