Januz–aktive kinaz yolağının inhibisyonu,tümör nekroz faktör alfa ile indüklenen IL-18 biyoaktivitesini, kaspaz-1 inhibisyonu aracılığıyla, azaltır
Arthritis Research and Therapy 2014,16:R102
IL-18, a member of the IL-1 family, has been shown to play an important role in immune response and is involved in the pathogenesis of RA. The study objective was to examine the role of the JAK pathway in modulating TNFa-induced-IL18 bioactivity by reducing caspase-1 function. Caspase-1 is the protease that cleaves pro-IL-18 to IL-18, thereby activating it. In testing it was noted that by blocking the JAK pathway significantly decreased caspase-1 transcription, expression and activity showing th...