Romatoid artritte tedavi için terapötik fırsat olarak TNFα ve IL-17’nin kombine inhibisyonu: Yeni bir bispesifik antikorun geliştirilmesi ve nitelendirilmesi.
Arthritis Rheumatol. 2015;67(1):51–62
Single cytokine inhibition, e.g. TNFα or IL-6, has fundamentally improved the therapeutic armamentarium for the treatment of RA; yet clinically meaningful responses are achieved in only about half of RA patients treated. In addition, it is now well established that the pathogenesis of RA involves multiple mechanisms of cell activation and cell recruitment. These two factors have led to the emergence of the concept of dual specificity, sparking interest in the biologic arena, with a focus o...