August 2022

Upadacitinib pour le traitement de la spondylarthrite axiale active non radiographique (SELECT-AXIS 2) : Essai de phase 3 randomisé, en double aveugle, contrôlé par placebo

Lancet 2022 doi: 10.1016/S0140-6736(22)01212-0

Upadacitinib significantly improved the signs and symptoms of nr-axSpA compared with placebo at Week 14 in this investigation. Prior to this, upadacitinib had been shown to be effective in patients with AS. This study aimed to assess the efficacy and safety of upadacitinib in non-radiographic axial spondyloarthritis.

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June 2022

Effet du Tofacitinib sur la douleur, la fatigue, la qualité de vie liée à la santé et la productivité au travail chez les patients atteints de spondylarthrite ankylosante active : Résultats d'un essai de phase III, randomisé, en double aveugle, contrôlé par placebo

RMD Open 2022 doi:10.1136/rmdopen-2022-002253

Navarro-Compán et al, determined the effectiveness of tofacitinib in patients with active ankylosing spondylitis in a Phase III, randomised, double-blind, placebo-controlled trial.

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Effet du sécukinumab sur les facteurs de risque cardiovasculaire traditionnels et les biomarqueurs inflammatoires : Analyses post-hoc de données regroupées pour trois indications

Rheumatol Ther 2022 Jun;9(3):935-955. Doi: 10.1007/s40744-022-00434-z

Merola et al., reported the effect of interleukin (IL)-17A inhibition with secukinumab on cardiovascular (CV) risk parameters in patients with psoriasis, psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA) over 1 year of treatment. This study evaluated data from 19 secukinumab related clinical trials in phase 3/4 in psoriasis, PsA, and axSpA.

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Le filgotinib diminue l'inflammation du corps vertébral et de la colonne postéro-latérale dans la spondylarthrite ankylosante : Résultats de l'essai TORTUGA

Rheumatology 2022;61:2388–2397. doi: 10.1093/rheumatology/keab758

Maksymowych et al., assessed the effects of filgotinib on inflammatory and structural changes at various spinal locations, based on MRI measures in patients with active ankylosing spondylitis in the TORTUGA trial. Correlations between changes in the inflammation score and clinical outcomes were also evaluated.

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May 2022

Durée de traitement des médicaments biologiques et des nouveaux immunomodulateurs dans la polyarthrite rhumatoïde, la spondylarthrite axiale, le rhumatisme psoriasique et le psoriasis - Étude de cohorte nationale à partir des registres DANBIO et DERMBIO

Semin Arthritis Rheum. 2022 doi: 10.1016/j.semarthrit.2022.151979

The authors reviewed drug survival of therapies across common inflammatory skin and joint conditions from national registries.  The findings highlighted that despite the overlapping pathogenesis of these conditions there was little similarity in drug survival. This reinforces the need for an individualised treatment approach consistent with the underlying disease, patient profile and treatment history.

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Traitement de la spondyloarthrite axiale : une mise à jour

Nat Rev Rheumatol. 18, 205–216 (2022) 2022 doi: 10.1038/s41584-022-00761-z

In this review Danve and Deodhar report an update on modern axSpa treatment. They found that in the past two decades substantial progress in the diagnosis and management of axSpA has been witnessed. Whilst ASAS classification criteria have enabled earlier diagnosis the increased availability of novel therapies, evolving drug safety data and novel clinical trials have allowed clinicians to rethink the placement and timing of drugs in disease management.

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Effets indésirables liés au système immunitaire (irEI) chez les patients atteints de spondylarthrite ankylosante (SA) traités par des inhibiteurs de l'interleukine (IL)-17 : étude systématique et méta-analyse

Inflammopharmacology. 2022, Apr;30(2):435-451. doi: 10.1007/s10787-022-00933-z

The most common immune system-related AEs in patients treated with IL-17 inhibitors are mucosal and opportunistic infections.

Interleukin (IL)-17 inhibitors are a series of biological drugs used to treat a number of conditions, including ankylosing spondylitis, a disease characterised by immune system dysregulation and joint inflammation. Azadeh, et al. aimed to assess the risk of immune system-related AEs due to targeting IL-17 or IL-17R.

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