Whole food diet induces remission in children and young adults with mild to moderate Crohn's disease and is more tolerable than exclusive enteral nutrition: A randomized controlled trial
Gastroenterology 2025;169:1462–74 Doi: 10.1053/j.gastro.2025.06.011
Aharoni-Frutkoff et al. demonstrated that tasty & healthy (T&H) ‘diet’ showed better tolerability than exclusive enteral nutrition (EEN) for inducing remission in mild to moderate CD, while positively affecting the microbiome. Authors explored the tolerability and effectiveness of the T&H diet compared with EEN in children and young adults with mild to moderate uncomplicated CD.
First controlled trial to provide comprehensive evidence for the effectiveness of an exclusive whole food diet in inducing remission in active CD. Quality of life improved in both groups without significant differences at Week 8. Patients following the T&H diet exhibited greater microbial diversity, with an increased presence of beneficial species leading to a microbiome with healthier characteristics than EEN.
