Association of BMI, BMR, BSA, and body weight with psoriasis severity and treatment response: Evidence from a real-world cohort
J Transl Med 2025;23:1129 Doi: 10.1186/s12967-025-07130-w
Xu et al. showed that elevated BMI, BSA, body weight, and basal metabolic rate are associated with more severe PsO and diminished treatment efficacy, especially for those treated with biologics. Authors investigated the associations of BMI, basal metabolic rate, BSA, and body weight with baseline PsO severity and therapeutic response across different treatment modalities.
Among various biologic agents, body size and metabolic parameters demonstrated the highest predictive value for clinical efficacy in ustekinumab-treated patients, suggesting a potential body size-dependent therapeutic effect.
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