Glucocorticoid sparing effect of Janus Kinase inhibitors compared to biological Disease Modifying Anti-Rheumatic Drugs in rheumatoid arthritis: A single-centre retrospective analysis
Journal Reference: Rheum. 2024 Epub ahead of print doi: 10.1093/rheumatology/keae455.
Adami et al. conducted a retrospective analysis to evaluate the GC sparing effects of JAKi versus bDMARDs in rheumatoid arthritis patients. They found that JAKi therapy was associated with a significant reduction in GC dose compared with bDMARDs. This suggests that JAKi could be more effective in reducing long-term GC exposure in RA patients.
The study included a cohort from a single centre and compared the efficacy of JAKi and bDMARDs in reducing GC dosage in a real-world setting. The primary outcome was the change in GC dose from baseline.
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