The association between genetics and response to treatment with biologics in patients with psoriasis, psoriatic arthritis, rheumatoid arthritis, and inflammatory bowel diseases: A systematic review and meta-analysis
Journal Reference: Int J Mol Sci 2024;25:5793 doi: 10.3390/ijms25115793
Genetic variants in TNFα, NLRP3, MYD88, and FcRγ genes were associated with a response to TNFi, when assessing several inflammatory diseases together. Al-Sofi et al. conducted a systematic review and meta-analysis on single nucleotide polymorphism (SNP) genetic markers and their response to biologics in psoriasis, PsA, RA, IBD, and across all chronic inflammatory diseases together.
MYD88 was associated with good a response to TNFi while NLRP3, TNF-308, and FCGR3A were associated with a bad response to TNFi; FCGR3A and TNF-238 were associated with a poor response to infliximab alone. None of the individual SNPs alone could predict whether a patient will respond to a given biologic.
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