Deucravacitinib, a selective, allosteric tyrosine kinase 2 inhibitor, in scalp psoriasis: A subset analysis of two Phase 3 randomized trials in plaque psoriasis
Am Acad Dermatol 2023. doi: 10.1016/j.jaad.2023.11.060
This pooled analysis of the Phase 3 PSO-1 and PSO-2 trials shows that deucravacitinib has greater efficacy in treating scalp PsO than placebo and apremilast. At week 16, response rates were greater with deucravacitinib versus placebo or apremilast for scalp-specific Physician Global Assessment 0/1 and Psoriasis Scalp Severity Index. Efficacy was maintained through 52 weeks in patients who received continuous deucravacitinib treatment.
Blauvelt et al pooled data from PSO-1 and PSO-2, which had identical trial designs up to Week 24. Patients with PsO were randomised 1:2:1 to placebo, deucravacitinib and apremilast in both studies.
