Baricitinib in Juvenile Idiopathic Arthritis: An International, Phase 3, Randomised, Double-blind, Placebo-controlled, Withdrawal, Efficacy, and Safety Trial
Lancet. 2023;402(10401):555–570 doi 10.1016/S0140-6736(23)00921-2
Phase 3 trial of baricitinib demonstrates efficacy with acceptable safety profile in polyarticular and extended oligoarticular juvenile idiopathic arthritis, juvenile psoriatic arthritis and enthesitis-related arthritis.
Improvements in multiple disease activity and HRQoL measures, such as JADAS-27 and CHQPF50 Physical and Psychosocial summary scales, respectively, were observed. These exceeded those of patients who were exposed to placebo.
In addition, the safety profile observed was consistent with that found in adult patients. These findings indicate a favourable risk-benefit balance for baricitinib in juvenile idiopathic arthritis, suggesting baricitinib offers a once-daily oral therapeutic alternative to available therapies.
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