Identificación de Dos Subpoblaciones de Tofacitinib con Diferentes Riesgos Relativos frente a Inhibidores TNF: Un análisis del estudio abierto aleatorizado controlado ORAL Surveillance
Ann Rheum Dis. 2023;82(7):901-910 doi: 10.1136/ard-2022-223715
Findings from a post hoc analysis of ORAL Surveillance can help guide individualised benefit/risk assessment and clinical decision-making on treatment with tofacitinib, based on identification of subpopulations ‘at risk’.
Previous analyses from ORAL Surveillance have identified age and smoking as independent risk factors of interest across safety outcomes. Based on these findings, Kristensen, et al. aimed to find easily identifiable and clinically practical subpopulations with different relative risk vs TNFi (i.e., ‘high-risk’ and ‘low-risk’).
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