Safety of Biological and Targeted Synthetic Disease-Modifying Antirheumatic Drugs for Rheumatoid Arthritis as used in Clinical Practice: Results from the ARTIS Programme

Nationwide register-based cohort study corroborates and extends previous evidence that the currently available biologic/targeted synthetic DMARDs have an acceptable and, on the whole, similar safety profile.

Frisell, et al. provide a comprehensive assessment of safety outcomes of particular interest, for most biologic/targeted synthetic DMARDs available for the treatment of RA. They highlight some differences concerning tolerability, specific infection risks, and certain serious, but rare, outcomes, and conclude that these data should be combined with corresponding data on effectiveness to inform risk-benefit trade-offs.