TNFI阻害薬の体軸性脊椎関節炎の炎症、構造および骨増殖性病変に対する効果 – SIJと脊椎のPET/MRIを 用いた前向きPOC試験
Arthritis Rheumatol. 2022 doi: 10.1002/art.42149
Clinically active r-axSpA patients (n=16) were treated with TNFi and imaged using Na[18F]F-PET/MRI of the sacroiliac joints (SIJ) and spine (n=10) at one week of treatment and at 3-6 months progression. Images were evaluated by three, blinded to timepoints, readers
Overall, there was a clinical improvement on the group level, as assessed by a decrease of BASDAI and ASDAS, including a significant decrease of CRP values. Significant reduction of bone marrow edema, both in the SIJ and the spine was observed.
In conclusion, anti-TNF treatment led to significant decrease of osteoblastic activity within 3-6 months at sites with inflammation.
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