June 2023

Mejora de los resultados informados por los pacientes y de la productividad laboral después de 3 años de tratamiento con Ustekinumab o un inhibidor del factor de necrosis tumoral en pacientes con artritis psoriásica: Resultados del estudio de mundo real PsABio

Arthritis Res Ther. 2023 Jun 23;25(1):109. doi: 10.1186/s13075-023-03058-y

Results from the 3-year PsABio study demonstrated that, generally, ustekinumab and TNFi treatment led to an improvement in PROs. In coming to this conclusion, researchers aimed to evaluate the real-world effect of ustekinumab or a TNFi on PRO and their association with effectiveness endpoints in PsA patients over 3 years.

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Tofacitinib Reduce la Inflamación Espinal en Cuerpos Vertebrales y Elementos Posterolaterales en la Espondilitis Anquilosante: Resultados de un ensayo de fase 2

Rheumatol Ther. 2023;10(4):1001–1020 doi 10.1007/s40744-023-00564-y

Tofacitinib treatment is associated with a significant improvement in CANDEN MRI scores of spinal inflammation in axSpA patients. This study by Østergaard, et al. also validates the CANDEN MRI scoring system as an approach for measuring axSpA-associated inflammatory lesions.

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Efecto de golimumab intravenoso en la fatiga y la relación con la respuesta clínica en adultos con espondilitis anquilosante activa en el estudio de fase 3 estudio de fase 3 GO-ALIVE

Rheumatol Ther. 2023;10(4):983–999 doi 10.1007/s40744-023-00556-y

Administration of IV-golimumab 2 mg/kg improves fatigue symptoms in axial spondylitis in a 52 Week study. At Week 16 of treatment, improvements in ASAS, ASDAS, BASDAI and SF-36 scores were observed at week 16 of treatment.

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Análisis post hoc de pacientes con artritis reumatoide en remisión clínica en dos ensayos japoneses de fase 3 de Peficitinib (RAJ3 y RAJ4)

Mod Rheumatol 2023;34(3):453–65 doi: 10.1093/mr/road059

Pots hoc analysis of peficitinib Phase 3 trials shows that continued treatment with peficitinib up to Week 52 is linked to improved remission rates in Asian patients with RA.

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Seguridad a largo plazo de Apremilast hasta 5 años a partir de 15 Estudios agrupados aleatorizados y controlados con placebo en psoriasis, artritis psoriásica y síndrome de Behçet

Am J Clin Dermatol. 2023;24(5):809-820 doi: 10.1007/s40257-023-00783-7

This study confirms the safety of long-term apremilast use in patients with plaque PsO, active PsA, or oral ulcers associated with Behçet’s syndrome. In coming to this conclusion, investigators conducted a pooled analysis of apremilast data from 15 clinical studies with open-label extension phases, focusing on long-term safety.

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Perfil de seguridad de upadacitinib en pacientes con riesgo cardiovascular: Análisis post hoc integrado del programa clínico de fase III SELECT en la artritis reumatoide

Ann Rheum Dis. 2023 doi: 10.1136/ard-2023-223916

Pots hoc analysis of safety data in patients with RA at increased risk of CV events from the upadacitinib SELECT phase III RA clinical programme helps to contextualise the overall risk profile of upadacitinib.

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Efecto de Upadacitinib en la actividad de la enfermedad, el dolor, la fatiga, la función, la calidad de vida relacionada con la salud y la productividad laboral en la espondilitis anquilosante refractaria al tratamiento con fármacos biológicos

Rheumatol Ther 2023; 10:679–91 doi 10.1007/s40744-023-00536-2

Upadacitinib significantly improved patient-reported outcomes in AxSpA patients with bDMARD-IR after 14 Weeks of treatment. There were notable improvements in disease activity, pain, fatigue, function, HRQoL, and work productivity.

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April 2023

Incidencia de enfermedad pulmonar intersticial en pacientes con artritis reumatoide tratados con fármacos antirreumáticos modificadores de la enfermedad biológicos y sintéticos dirigidos

JAMA Netw Open. 2023;6(3):e233640 doi: 10.1001/jamanetworkopen.2023.3640

Retrospective cohort study results suggest that treatment with tofacitinib, and perhaps other JAK inhibitors, may provide a benefit in reducing the risk of developing RA-Interstitial Lung Disease (ILD).

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Guselkumab, un inhibidor selectivo de la subunidad p19 de la Interleukina-23, resuelve la dactilitis en pacientes con artritis psoriásica activa: resultados agrupados a lo largo de 52 semanas desde dos estudios de fase 3

ACR Open Rheumatol. 2023;5(4):227–240 doi 10.1002/acr2.11537

Post hoc analysis of guselkumab, Phase 3 DISCOVER-1 and -2 studies finds that 75% of guselkumab-randomised patients have complete resolution of dactylitis through one year.

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Factores asociados a la retención de secukinumab en pacientes con espondiloartritis axial en la práctica del mundo real: Resultados de un estudio retrospectivo (FORSYA)

RMD Open 2023;9:e002802 doi: 10.1136/rmdopen-2022-002802

This study reported the overall retention of secukinumab in daily practice in the period following its approval in France was approximately 59% at 1 year in axSpA patients. The aim of this study was to determine whether OSI were predictive of secukinumab retention at 1 year.

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