A Network Meta-Analysis Comparing Efficacy and Safety of Tofacitinib and Baricitinib
Z Rheumatol. 2018 Sep 6. DOI 10.1007/s00393-018-0531-5
Tofacitinib (TOF) 10mg and baricitinib (BARI) 4mg, in combination with methotrexate (MTX), were the most efficacious treatments in RA patients with an inadequate response to DMARDs or biologics. Both combination treatments presented acceptable safety profiles and were not associated with a significant risk of serious adverse events.This study employed a Bayesian approach to Meta-Analysis; combining the available evidence across a network of Randomised Controlled trials (RCTs).Twelve RCTs contai...