March 2023

Baixas Taxas de Progressão Radiográfica Associadas com Eficácia Clínica em até 2 anos de Seguimento Após Tratamento com Guselkumab: Resultados de um Ensaio Clínico Randomizado de Fase 3, Duplo-Cego, Controlado com Placebo com Pacientes Naïve a Biológicos com Artrite Psoriásica Ativa

RMD Open. 2023 doi: 10.1136/rmdopen-2022-002789

Data from this paper provides a robust analysis of radiographic progression through 2 years in a phase 3 study of guselkumab in patients with PsA. This study sought to evaluate the relationship between radiographic progression and clinical outcomes in post hoc analyses of patients with PsA receiving up to 2 years of guselkumab therapy in DISCOVER-2.

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Upadacitinib Induction and Maintenance Therapy for Crohn’s Disease

N Engl J Med 2023; 388:1966–1980 doi: 10.1056/NEJMoa2212728

Upadacitinib was associated with higher percentages of remission and endoscopic response regardless of previous failure of biologic therapy. This paper reports the Phase 3 efficacy and safety results of upadacitinib in patients with moderate-to-severe Crohn’s disease.

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Segurança de Medicamentos Biológicos Sintéticos e Modificadores de Doença Direcionados na Artrite Reumatoide como Usados na Prática Clínica: resultados do programa ARTIS

Ann Rheum Dis. 2023;82(5):601–610 doi: 10.1136/ard-2022-223762

Nationwide register-based cohort study corroborates and extends previous evidence that the currently available biologic/targeted synthetic DMARDs have an acceptable and, on the whole, similar safety profile.

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Risco de malignidade com tofacitinibe versus inibidores de TNF na artrite reumatoide: Resultados do Estudo Open-Label, Randomizado e Controlado ORAL Surveillance

Ann Rheum Dis. 2023;82(3):331–343 doi: 10.1136/ard-2022-222543

Results from the open-label, randomised controlled ORAL Surveillance trial find increased risk of malignancies with tofacitinib versus TNFi, highlighting the highest incidence in patients with a history of atherosclerotic cardiovascular disease or increasing cardiovascular risk.

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February 2023

Herpes Zoster em Pacientes com Artrite Inflamatória ou Colite Ulcerativa Tratados com Tofacitinib, Baricitinib ou Upadacitinib: uma revisão sistemática de estudos clínicos e do mundo real

Overall, this evidence supports that HZ-risk is a “class” effect of JAKi, observing a higher risk compared to other non-biologic/biologic drugs . This study aimed to systematically review the incidence of HZ among RA, PsA, AS and UC patients treated with TOFA, BARI or UPA.

Overall, this evidence supports that HZ-risk is a “class” effect of JAKi, observing a higher risk compared to other non-biologic/biologic drugs . This study aimed to systematically review the incidence of HZ among RA, PsA, AS and UC patients treated with TOFA, BARI or UPA.

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Impacto do Enriquecimento do Risco Cardiovascular na Incidência de Eventos Adversos Cardiovasculares Graves no Programa Clínico de Tofacitinibe em Artrite Reumatoide

Ann Rheum Dis. 2023;82(4):575–577 doi: 10.1136/ard-2022-223406

Data suggest that an important difference between P123LTE and ORAL Surveillance was the proportion of patients with a history of atherosclerotic CV disease (ASCVD).

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January 2023

Segurança e Eficácia de Bimekizumabe em Pacientes com Espondite Anquilosante Ativa: resultados de três anos de um estudo de fase IIb randomizado controlado e seu estudo de extensão aberto

Arthritis Rheumatol. 2022;74:1943–58

In this open-label extension study of BE AGILE, the safety profile of bimekizumab was found to be consistent with previously demonstrated findings, and no new safety signals were identified. The objective was to assess the long-term safety, tolerability, and efficacy of bimekizumab in patients with active AS.

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Eventos Adversos de Influenza em Pacientes com Artrite Reumatoide, Retocolite Ulcerativa ou Pacientes com Artrite Psoriásica nos Programas de Desenvolvimento Clínico de Tofacitinib

Rheumatol Ther. 2022. Epub ahead of print doi: 10.1007/s40744-022-00507-z

This post-hoc analysis of 31 clinical trials in ulcerative colitis, rheumatoid arthritis and psoriatic arthritis concludes that combined influenza adverse event incidence rates were highest in ulcerative colitis, while in each indication they were generally similar across tofacitinib, placebo, and comparator groups.

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Análise das Medidas de Atividade da Doença em um Estudo de Redução de Metotrexato em Pacientes com Artrite Reumatoide Tratados com Tofacitinib e Metotrexato

Rheumatol Ther. 2022. Epub ahead of print doi: 10.1007/s40744-022-00511-3

This post hoc analysis of data from the ORAL Shift study, concludes that DAS28-4(ESR), CDAI remission and SDAI remission are the metrics most likely to reflect actual disease activity, in the context of tofacitinib in a randomised withdrawal of MTX.

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December 2022

Treatment Persistence of Tumour Necrosis Factors And IL-17 Inhibitors in Axial Spondyloarthritis: A Multi-Center Comparative Analysis

Joint Bone Spine 2022; 89:105416 doi: 10.1016/j.jbspin.2022.105416

In this multi-centric, real-world study, persistence with secukinumab and TNFi were not statistically different for matched populations. The primary outcome of this analysis was drug persistence, calculated as the difference in months between initiation and discontinuation.

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