TNF Inhibitörlerine Yetersiz Yanıtlı Aktif Romatoid Artrit Hastalarında Tofasitinib ve Biyolojik Tedavilerin Karşılaştırılması: Bir Network Meta Analizinin Sonuçları
Clin Ther 2016;38:2628–40.
This network meta-analysis, performed within a Bayesian framework, concluded that tofacitinib 5 mg BID has efficacy and AE rates comparable with currently available bDMARDs over a 24-week period in patients experiencing an inadequate response to TNF therapy. A systematic literature search identified five, Phase 2 or beyond, randomised controlled trials for inclusion in the analysis. Each trial had an adult population with moderate to severe RA, with inadequate response (IR) or failed treatment w...