IL-6 Yolağı Inhibitörü Alan Romatoid Artritli Hastalarında 28 Eklemli Hastalık Aktivite Skoru (DAS28) için Yeni Önerilen Remisyon Kesim Noktalarının Değerlendirilmesi
Arthritis Res Ther. 2017 Jul 4;19(1):155. doi: 10.1186/s13075-017-1346-5
DAS28 is not currently included in the joint remission definitions of the ACR and the EULAR because its formula is disproportionately influenced by Acute Phase Response (APR).IL-6 pathway blockers or JAK inhibitors greatly reduce APR, causing patients to be classed as in DAS28 remission despite still having multiple swollen joints.To make DAS28 remission criteria more stringent, the alternative cut-points of <1.9 and <2.2 for CRP and ESR, respectively, have been proposed.This study questioned th...