Publications

View and download slide summaries of the latest original articles focusing on therapies in immune-mediated inflammatory diseases including rheumatology, dermatology, and gastroenterology. All materials produced by the team are subsequently reviewed and approved by individual Steering Committee members.

July 2017

Romatoid Artrit Hastalarında Tofasitinib Monoterapisinin, Metotreksat ile Tofasitinibin ve Metotreksat ile Adalimumab Kombinasyonunun Etkinliği ve Güvenliği (ORAL Strategy): Faz 3b/4, Çift Kör, Kafa-kafaya, Randomize Kontrollü Bir Çalışma

Lancet. 2017 Jul 29;390(10093):457-468. doi: 10.1016/S0140-6736(17)31618-5

Fleischmann R,

Mysler E,

Hall S,

Kivitz A,

Moots R,

Luo Z,

DeMasi R,

Soma K,

Zhang R,

Menon S,

on behalf of the ORAL Strategy investigators

In this first head-to-head non-inferiority trial assessing a JAKi ± MTX directly compared with a TNFi + MTX in patients with RA, tofacitinib (TOF) + MTX showed non-inferiority to adalimumab (ADA) + MTX. Non-inferiority was not shown for TOF monotherapy versus TOF + MTX, or versus ADA + MTX.In this 52-week study, MTX-inadequate responder (IR) patients were randomised 1:1:1 to receive TOF 5 mg BID monotherapy, TOF 5 mg BID + MTX or ADA 40 mg every other week + MTX. The primary endpoint, ACR50 resp...

Keywords:

April 2017

Romatoid Artrit Tedavisinde Sentetik ve Biyolojik Modifiye Antiromatizmal İlaçlar EULAR Önerileri: 2016 Güncellemesi

Ann Rheum Dis Published Online First: 06March2017. doi:10.1136/annrheumdis-2016-210715

EULAR RA Management Task Force Smolen J,

Landewé R,

Bijlsma J,

et al

The EULAR 2016 recommendations update, based on three systematic literature reviews (SLRs) and expert opinion, comprises four overarching principles and 12 recommendations compared with 14, respectively, in 2013. These recommendations intend to inform regarding EULAR’s most recent consensus on the management of RA, with the aim of attaining the best outcomes with current therapies.All DMARD types: csDMARDs, bDMARDs, tsDMARD and bsDMARD are addressed, and cost aspects are taken into consideration...

Keywords:

EULAR