Aktif Romatoid Artrit Tedavisinde Monoterapi veya Kombinasyon Terapisi Olarak Tocilizumab: Randomize Kontrollü Çalışmalardaki Etkinlik ve Güvenlik Verilerinin Meta-analizi
Arthritis Res Ther 2016; 18:211. DOI 10.1186/s13075-016-1108-9
This is the first meta-analysis comparing efficacy and safety of TCZ monotherapy (TCZMONO) versus TCZ + csDMARD (TCZCOMBI) in patients with RA. The findings show that similar efficacy can be expected with TCZ monotherapy in patients with intolerance to csDMARDs compared with inadequate responders to csDMARDs who switch to TCZ add-on therapy.A total of 6679 patients from 13 studies were included, receiving: 1298, TCZMONO; 3077, TCZCOMBI; 2204, csDMARDs. Meta-analyses were performed for the follow...