Tofacitinibe versus metotrexato como medicamentos antirreumáticos modificadores de doença de primeira linha no tratamento da artrite reumatoide: Um estudo aberto, randomizado e controlado
Int J Rheum Dis. 2023;26(9):1729–1736 doi: 10.1111/1756-185X.14801
This single-centre study by Khan, et al. suggests that high-dose methotrexate (25 mg/week, subcutaneously) may be as efficacious as tofacitinib in patients with established RA who are DMARD naïve or have not received a therapeutic dose of DMARDs.