Segurança e Efetividade de Upadacitinib ou Adalimumab mais Metotrexato em Pacientes com Artrite Reumatoide Mais de 48 Semanas com Troca para Terapia Alternativa em Pacientes com Resposta Insuficiente
Ann Rheum Dis 2019 DOI: 10.1136/annrheumdis-2019-215764
Consistent with Wk26 data, significantly more UPA patients achieved LDA and remission versus ADA and PBO over 48 weeks. RA patients often change therapy due to inadequate response and intolerance. The SELECT COMPARE study was designed to explore switching to JAK inhibitors from TNF inhibitors without a wash-out period (and vice versa). The long-term safety and efficacy of UPA was compared to ADA and PBO in MTX-IR.1629 patients were blindly assigned 2:2:1 to; UPA 15mg QD, ADA 40mg Q2W and PBO, wi...