TNF阻害薬効果不十分の活動性乾癬性関節炎に対するC secukinumab, ixekizumab, および tofacitinib の同等の有効性
Int J Clin Pharmacol Ther. 2021. Epub ahead of print.
Bayesian network meta-analysis of randomised controlled trials (RCTs) highlights the effectiveness of secukinumab, ixekizumab, and tofacitinib in patients with psoriatic arthritis (PsA) and an inadequate response to tumour necrosis factor inhibitors (TNFi).There is a current need for therapies with alternative mechanisms of actions to DMARDs and TNFi, for the significant proportion of patients with PsA who insufficiently respond to these therapies. While RCTs for therapies such as secukinumab a...