Effetto dei Glucocorticoidi sull’Efficacia Clinica e Radiografica di Tofacitinib nei Pazienti con Artrite Reumatoide: Analisi Post-hoc di Dati da 6 Studi di Fase III
J Rheumatol 2018 Feb; 45(2):177-87
In this post hoc analysis, six Phase 3 studies were used to analyse the effect of glucocorticoids (GC) on the efficacy of tofacitinib (TOF) in patients with RA. Concomitant use of GC did not affect the clinical or radiographic outcomes of patients treated with TOF. Data from all six clinical trials were evaluated, with four studies (ORAL Scan, ORAL Standard, ORAL Sync and ORAL Step) being pooled for analysis. In these studies, MTX was used as a comparison and patients were required to maintain a...