September 2020

Évaluation de l'association des anticorps anti-CarbV et anti-MCV avec la réponse au traitement et la progression radiographique dans une population de patients PR traités soit par le méthotrexate soit par le baricitinib : analyses post-hoc de RA-BEGIN

Arthritis Res Ther. 2020;22(1):193

Autoantibodies associated with the onset of RA have gained attention in recent years as prognostic biomarkers. Though not used diagnostically, anti-CarbV (carbamylated vimentin) and anti-MCV (vimentin modified by citrullination) baseline titers are being investigated as predictors of treatment response. In this post-hoc analysis of data from the RA-BEGIN cohort of active RA patients, López-Romero and colleagues consider the potential predictive values of baseline anti-CarbV and anti-MCV titers r...

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August 2020

Efficacité et Innocuité de l’Upadacitinib en Monothérapie Chez les Patients Méthotrexate-Naïfs Avec une Polyarthrite Rhumatoïde Modérément À Sévèrement Active (Select-early) : Un Essai Randomisé, en Double Aveugle, À Comparateur Actif, Multicentrique et Multinational

Arthritis Rheumatol 2020

Upadacitinib monotherapy demonstrated superior clinical, radiographic, and patient-reported outcomes versus methotrexate in methotrexate-naïve RA patients.This 48-week double-blind active comparator study investigated upadacitinib monotherapy in patients with early RA, who were either methotrexate-naïve, or who had very limited exposure. 947 patients were randomised to once-daily upadacitinib 15 or 30 mg, or weekly methotrexate. Unusually, there were two separate primary endpoints, selected for ...

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July 2020

Traitement pharmacologique du rhumatisme psoriasique : Une recherche littéraire systématique pour la mise à jour de 2019 des recommandations EULAR sur la gestion du rhumatisme psoriasique

Annals of the Rheumatic Diseases 2020;79:778-786

This SLR reviewed data on pharmacological treatment of PsA. Findings informed the 2019 EULAR taskforce when updating recommendations for PsA management. Overall, no new safety signals were reported. Encouragingly, LTEs of JAKi did not report any venous thromboembolic events or PEs. Efficacy was demonstrated for a range of bDMARD and tsDMARD therapies in various disease domains. Efficacy varied between PsA manifestations and between therapies. Observational data demonstrated efficacy when switchi...

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