Publications

View and download slide summaries of the latest original articles focusing on therapies in immune-mediated inflammatory diseases including rheumatology, dermatology, and gastroenterology. All materials produced by the team are subsequently reviewed and approved by individual Steering Committee members.

November 2023

Effets d'un traitement d'un an par le tofacitinib sur les biomarqueurs angiogéniques dans la polyarthrite rhumatoïde

Rheumatology (Oxford) 2023; 62(SI3):SI304–SI312 doi 10.1093/rheumatology/kead502

Hamar A,

Tajti G,

Végh E,

Soós B,

Panyi G,

Seres T,

Szűcs G,

Szekanecz Z

This study by Kerekes, et al. investigated the relationship between tofacitinib therapy, angiogenic biomarker levels, and vascular inflammation and function in RA patients. The authors found that tofacitinib treatment reduced the production of bFGF, PlGF and IL-6, which may inhibit synovial and aortic inflammation.

Keywords:

Tofacitinib

September 2023

Le guselkumab modifie les gènes différentiellement exprimés dans le sang des patients atteints de rhumatisme psoriasique : Résultats de deux essais de phase 3, randomisés et contrôlés par placebo

ACR Open Rheumatol. 2023 doi: 10.1002/acr2.11589

Hsia EC,

Xu XL,

Song Q,

Gao S,

Chen W,

Miron M

Whole blood transcriptome profiling reveals differential gene expression in patients with active PsA from the DISCOVER-1 and DISCOVER-2 clinical studies in comparison with healthy controls.

Keywords:

August 2023

Le pipeline 2023 des médicaments antirhumatismaux modificateurs de la maladie (DMARD) en développement clinique pour la spondylarthrite (y compris le rhumatisme psoriasique) : Une revue systématique des essais

RMD Open. 2023;9(3):e003279 doi 10.1136/rmdopen-2023-003279 https://pubmed.ncbi.nlm.nih.gov/37507210/

Denis A,

This systematic review identified DMARDs evaluated for axSpA and PsA, distinguishing between csDMARDs, tsDMARDs, and bDMARDs. The review pinpointed twenty-six distinct targeted therapies currently in clinical development; 18 therapies for axSpA and 15 therapies for PsA.

Keywords:

Review

Le filgotinib modifie les biomarqueurs des protéines du sang périphérique associés à l'inflammation chez les adultes atteints de polyarthrite rhumatoïde active et avec réponse inadéquate antérieure au méthotrexate

Rheumatol Ther. 2023;10(5):1335–1348 doi 10.1007/s40744-023-00583-9

Tanaka Y,

Taylor PC,

Elboudwarej E,

Hertz A,

Shao X,

Emoto K,

This study by Tanaka, et al. shows that filgotinib reduces peripheral protein biomarkers associated with JAK/STAT signalling, inflammatory signalling, immune cell migration, and bone resorption in RA patients. Notably, filgotinib 200 mg significantly reduced IL-6, TNF, CXCL13 levels as early as Week 4.