Publications

View and download slide summaries of the latest original articles focusing on therapies in immune-mediated inflammatory diseases including rheumatology, dermatology, and gastroenterology. All materials produced by the team are subsequently reviewed and approved by individual Steering Committee members.

April 2023

Guselkumab, un inhibidor selectivo de la subunidad p19 de la Interleukina-23, resuelve la dactilitis en pacientes con artritis psoriásica activa: resultados agrupados a lo largo de 52 semanas desde dos estudios de fase 3

ACR Open Rheumatol. 2023;5(4):227–240 doi 10.1002/acr2.11537

Shawi M,

Xu XL,

Sheng S,

Xu S,

Ritchlin CT,

Rahman P,

Mease PJ

Post hoc analysis of guselkumab, Phase 3 DISCOVER-1 and -2 studies finds that 75% of guselkumab-randomised patients have complete resolution of dactylitis through one year.

Keywords:

Eficacia y Seguridad Multidominios de Guselkumab a lo largo de 1 Año en Pacientes con Artritis Psoriásica Activa con y sin Exposición a Inhibidores del Factor de Necrosis Tumoral: Análisis del Ensayo de Fase 3, Aleatorizado, Controlado con Placebo DISCOVER-1

ACR Open Rheumatol. 2023 doi: 10.1002/acr2.11523

Xu XL,

Shawi M,

Jiang Y,

Sheng S,

Helliwell PS

TNF inhibitors (TNFi) are one main mode of therapy in patients with PsA who fail to respond to csDMARDs. However, they have a primary treatment failure rate of 40% and only a modest target of ≥20% ACR20 response. The objective of this study was to evaluate efficacy and safety of guselkumab, interleukin-23 inhibitor in the DISCOVER-1 study with active PsA patients by prior use of TNFi.

Keywords:

March 2023

Bajas Tasas de Progresión Radiográfica Asociadas con Eficacia Clínica Siguiendo hasta 2 Años de Tratamiento con Guselkumab: Resultados de un Ensayo Clínico Aleatorizado de Fase 3, Doble Ciego, Controlado con Placebo con Pacientes Naïve de Biológicos con Artritis Psoriasica Activa

RMD Open. 2023 doi: 10.1136/rmdopen-2022-002789

Xu XL,

Jiang Y,

Sheng S,

Shawi M,

Chakravarty SD,

Lavie F,

Mease PJ

Data from this paper provides a robust analysis of radiographic progression through 2 years in a phase 3 study of guselkumab in patients with PsA. This study sought to evaluate the relationship between radiographic progression and clinical outcomes in post hoc analyses of patients with PsA receiving up to 2 years of guselkumab therapy in DISCOVER-2.