Inhibitors of switch kinase ‘spleen tyrosine kinase’ in inflammation and immune-mediated disorders: A review
European Journal of Medicinal Chemistry 2013 67:434–446
SYK plays a significant role in the immune cell signalling of B cells, mast cells, macrophages and neutrophils. Kaur et al. provide a comprehensive review of the molecule, its role in autoimmune disease and clinical data on its inhibition. The paper covers the basic chemistry of SYK including structure, mechanism of action, synthetic derivatives and function, and the relevance of SYK as a therapeutic target for many autoimmune diseases is discussed. The SYK inhibitors currently in clinical trials (including fostamatinib (R788), R406 and R112) are reviewed, bringing together data from multiple trials to give an overview of development. The authors conclude that because autoimmune diseases involve multiple signalling pathways, inhibition of an upstream target such as SYK, which affects many biologic pathways, can be seen as a major treatment strategy in the future.
Slides coming soon
