Anti-gm-csf Otilimabe versus Sarilumab ou Placebo em Pacientes com Artrite Reumatoide e Resposta Inadequada a Terapias Direcionadas: Um Estudo Randomizado de Fase III (contRAst 3)

Ann Rheum Dis. 2023;82(12):1527–1537 doi 10.1136/ard-2023-224449

The ContRAst 3 study investigated otilimab, in RA patients with inadequate responses to multiple treatments. Otilimab did not significantly improve ACR20 versus placebo at Weeks 12 or 24. In addition, there we no significant improvements in secondary endpoints, including disease activity, disability, and pain.

In this 24-week, phase III trial by Taylor, et al., patients received otilimab, sarilumab, or placebo in addition to conventional RA medications. Otilimab did not demonstrate non-inferiority to sarilumab in any disease activity measure.

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Publication thumbnail: Anti-gm-csf Otilimabe versus Sarilumab ou Placebo em Pacientes com Artrite Reumatoide e Resposta Inadequada a Terapias Direcionadas: Um Estudo Randomizado de Fase III (contRAst 3)
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