トファシチニブ治療された関節リウマチ患者におけるパラオキソナーセ-1 ジェノタイプと主要心血管イベントおよび悪性腫瘍の関連
J Rheumatol. 2023 doi 10.3899/jrheum.2023-0112 Epub ahead of print
High paraoxonase activity is associated with a significantly reduced risk of MACE and non-NMSC malignancies in white/European RA patients. The PON1 Q192R RR genotype had a significantly greater association with paraoxonase versus the QQ genotype, but had no significant association with MACE or non-NMSC malignancies.
In this post-hoc analysis by Schoeman, et al., data were pooled from three Phase 2 RCTs and six Phase 3 RCTs, which included two LTE studies. PON1 was a gene of interest as tofacitinib increases its activity levels.
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