体軸型脊椎関節炎における倦怠感へのトファシチニブの効果は疼痛と炎症が介する: 経路分析
Rheumatol Ther 2023;10(4):1073–1087 doi 10.1007/s40744-023-00570-0
Kristensen, et al. used mediation modelling to show that tofacitinib indirectly improved fatigue symptoms via back pain and morning stiffness. This study was carried out using FACIT-F- and BASDAI Q1-based models to determine the relationship between these variables.
This modelling study by Kristensen, et al. used data from two tofacitinib trials: one phase 2 and one phase 3. Both studies were interventional, randomised, placebo-controlled, parallel,
quadruple-masking clinical trials.
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